Leukocyte-Derived Microparticles as Proinflammatory Mediators in Atherosclerosis
نویسندگان
چکیده
منابع مشابه
Circulating leukocyte-derived microparticles predict subclinical atherosclerosis burden in asymptomatic subjects.
OBJECTIVE To clarify circulating microparticles (MP) relationships with preclinical atherosclerosis. METHODS AND RESULTS In 216 subjects without cardiovascular disease, we assessed: (1) annexin V-positive, platelet-derived, endothelium-derived and leukocyte-derived circulating MP by capture on annexin V, anti-GPIb, anti-CD105, and anti-CD11a antibody-coated wells, respectively; (2) Framingham...
متن کاملLeukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis.
BACKGROUND We recently assigned a new fibrinolytic function to cell-derived microparticles in vitro. In this study we explored the relevance of this novel property of microparticles to the in vivo situation. DESIGN AND METHODS Circulating microparticles were isolated from the plasma of patients with thrombotic thrombocytopenic purpura or cardiovascular disease and from healthy subjects. Micro...
متن کاملMicroparticles as mediators and biomarkers of rheumatic disease.
Microparticles (MPs) are small membrane-bound vesicles that arise from activated and dying cells and enter the blood to display pro-inflammatory and pro-thrombotic activities. MPs are 0.1-1.0 μm in size and incorporate nuclear, cytoplasmic and membrane molecules as they detach from cells. This process can occur with cell activation as well as cell death, with particles likely corresponding to b...
متن کاملInflammatory mediators in atherosclerosis.
54. Carew, T. E., Schwenke, D. C. & Steinberg, D. ( 1 987) /’roc. Natl. Acad. Sci. U.S.A. 84,7725-7729 Quinn, M. T., Parthasarathy, S., Fong, L. G. & Steinberg, D. (1987) Proc. Natl. Acad. Sci. U.S.A. 84,2995-2998 Steinberg, D., Parthasarathy, S., Carew, T. E., Khoo, J. C . & Witztum, J. L. ( 1989) N . Engl. J. Med. 320,9 15-924 Gey, K. F., Puska, P., Jordan, P. & Moser, U. K. ( 1 990) Am. J. C...
متن کاملMicroparticles in Angiogenesis: Therapeutic Potential Formation, Fate, and Function of Platelet Microparticles Microparticles in Vascular Function and Atherothrombosis Leukocyte-Derived Microparticles in Vascular Homeostasis
Considered during the past decades as cell dust, microparticles are now deemed true biomarkers and vectors of biological information between cells. Depending on their origin, the composition of microparticles varies and the subsequent message transported by them, such as proteins, mRNA, or miRNA, can differ. Recent studies have described microparticles as “cargos” of deleterious information in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2013
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2013.04.054